At home, a third urine sample will be collected over 16 hours. Both of these samples are collected at NIH in the outpatient day hospital. Participants will collect three urine samples: one is collected over 4 hours, followed by a second over 4 hours. Participants come to the NIH Clinical Center for a medical history, physical examination, blood and urine tests, electrocardiogram (EKG) and echocardiogram (heart ultrasound). People 18 years of age and older with iron overload may be eligible for this study to undergo the following procedures: This study will see if the drug can increase the removal of iron into the urine in humans as well. Recently, nifedipine was found to cause iron loss in the urine of small animals. Treatments include reducing iron intake in the diet or removing the excess iron using medical therapies. Over time, it can cause problems with the liver, heart and glands. Iron overload can be caused by the body's inability to regulate iron or by medical treatments, such as multiple blood transfusions. This study will determine if nifedipine, a medication used to treat high blood pressure, can help treat iron overload, a condition in which the body contains too much iron.
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